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KMID : 0367419790200060055
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Journal of Korean Pediatric Society
1979 Volume.20 No. 6 p.55 ~ p.60
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Clinical Trials of Galantase for Infantile Diarrhea
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李謹洙/Lee, Keun Soo
李純鎔/李夏白/權赫商/Lee, Soon Yong/Lee, Ha Baik/Kwon, Hyeak Sang
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Abstract
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In 1962, Durand suggested the term "Primary lactose intolerance" for the disorder wihch resulted from a defect of the lactase activity in the intestinal mucosa. However primary lactose intolerance is rare and it is not commonly encountered in routine pediatric practice. Apart, from such a primary lactose intolerance, diarrhea, meteorism, and abdominal discomfort after taking lactose containing food are more frequently encountered in case of gastroenteritis in which damage of the intestinal mucosa and coating of the mucosa by inflammatory secretions lead to decreased lactase activity. This has been termed `Secondary lactose intolerance in order to differentiate it from the primary lactose intolerance. It is now considered that secondary lactose intolerance may play an important role in case of chronic infantile diarrhea commonly encoutered in pediatric practice.
The anther tried the lactase preparation "Galantase" to evaluated: it´s clinical effect on infantile diarrhea of various kind (50 cases).
Evaluation of the effect of Galantase was made on the beses.of the following criteria Marked effective; nature of stools and number per day returned to normal within 3 days after Galantase administration.
Effective; nature of stools and number per day decreased within 3 days after Galantase administration.
Slight effective; showed some improvement on it´s nature and number in general.
Ineffective; all stools remained unchainged and d:arrheic.
The results obtained by this study are as followes
Marked effective; 78%
Effective; 12%
Slight effective; 4%
Ineffective; 6%
There was no undesirable side effect observed in all 50 cases. Based upon the above effective rate, we concluded that the Galantase is a quite effective medicament for infantile diarrhea, especially forr_primary and secondary lactose intolerance.
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